SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME NEW QUINALDINE DERIVATIVES

A new series of quinoline derivatives incorporated to glycosides and biologically active heterocyclic moieties were synthesized starting with 6-bromo-4-hydroxyquinaldine (6-bromo-4-hydroxy-2-methylquinoline) compound 1. Some of the synthesized compounds were evaluated for their antibacterial and antifungal activities. Most of the tested compounds exhibited potential antibacterial activity against Gram-positive bacteria. the detailed synthesis, spectroscopic data. antibacterial and antifungal evaluation of the synthesized compounds are reported.