Higher-order structures of HIV Integrase: Drug-induced Aggregates of HIV Integrase are Weak Gels

From the Perelman School of Medicine, University of Pennsylvania. 1Department of Biochemistry and Biophysics 242 Anatomy-Chemistry Building Philadelphia, PA, 19104-6059 U.S.A. 2Department of Microbiology 3610 Hamilton Walk Philadelphia, PA 19104-6076 U.S.A. 3Department of Bioengineering and Departments of Physiology and Physics and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA, 19104, USA