Resting-state functional connectivity and amyloid burden influence longitudinal cortical thinning in the default mode network in preclinical Alzheimer’s disease

•Low baseline default-mode integrity and high amyloid presage future network atrophy.•The high amyloid group drives the within-network atrophy effect.•Alzheimer’s disease-related biomarkers didn’t explain the high amyloid group’s effect.•Results support links between functional and cortical integrity and connectivity as a protective factor.