PathSTORM: a road to early cancer detection
MOLECULAR & CELLULAR ONCOLOGY(2020)
摘要
Disruption of chromatin structure could enable early carcinogenesis by facilitating malignant transformation. Using stochastic optical reconstruction microscopy optimized for pathological tissue (PathSTORM), we uncovered a gradual decompaction of higher-order chromatin folding through progressive stages of carcinogenesis. We demonstrated potential detection of pre-cancerous genomic architecture not easily discernible by conventional pathology.
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关键词
PathSTORM,chromatin,CUT&RUN,oncogenesis,diagnostics
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