Drug Resistance Spread in 6 Metropolitan Regions, Germany, 2001–20181

Melanie Stecher,Antoine Chaillon,Christoph Stephan,Elena Knops,Niko Kohmer,Clara Lehmann,Josef Eberle,Johannes Bogner,Christoph D. Spinner,Anna Maria Eis-Huebinger,Jan-Christian Wasmuth,Guido Schaefer,Georg Behrens,Sanjay R. Mehta,Joerg Janne Vehreschild,Martin Hoenigl

Emerging infectious diseases（2020）

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摘要

We analyzed 1,397 HIV-1 pol sequences of antiretroviral therapy-naive patients in a total of 7 university hospitals in Bonn, Cologne, Frankfurt, Hamburg, Hannover, and Munich, Germany. Phylogenetic and network analysis elucidated numerous cases of shared drug resistance mutations among genetically linked patients; K103N was the most frequently shared mutation.

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关键词

HIV transmission,antimicrobial resistance,ART,antiretroviral therapy,mutations,phylogenetic analysis

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