Single-molecule FRET dynamics of molecular motors in an ABEL trap

Maria Dienerowitz,Jamieson A.L. Howard,Steven D. Quinn,Frank Dienerowitz,Mark C. Leake

Methods（2021）

引用 6|浏览13

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摘要

•Combines single molecule Förster Resonance Energy transfer with molecular confinement.•Anti-Brownian ELectrokinetic trapping enables observation times of up to 6 s.•Observes conformational switching events of molecular motor Rep with 1 ms time resolution.•Electric potential modelling in microfluidics chip.•Hidden Markov analysis of single-molecule Förster Resonance Energy trajectories.

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关键词

ABEL trap,Single-molecule FRET,Rep,Electrokinetic trapping,Hidden Markov modelling

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