Structural basis for lipid transport by the MLA complex

Daniel Mann,Junping Fan,Daniel P. Farrell,Kamolrat Somboon,Andrew Muenks,Svetomir B. Tzokov,Syma Khalid,Frank Dimaio,Samuel I. Miller,Julien R. C. Bergeron

biorxiv（2020）

引用 4|浏览28

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摘要

The maintenance of lipid asymmetry (MLA) system is involved in lipid transport from/to the outer membrane in gram-negative bacteria, and contributes to broad-range antibiotic resistance. Here, we report the cryo-EM structure of the MlaBDEF core complex, in the , ADP- and AppNHp-bound states. This reveals multiple lipid binding sites, and suggests a mechanism for their transport.

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关键词

lipid dynamics,inner membrane complex,lipid asymmetry,inner membrane

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