Discovery and Characterization of ORM‐11372, a Novel Inhibitor of the Sodium‐calcium Exchanger with Positive Inotropic Activity

Leena Otsomaa,Jouko Levijoki,Gerd Wohlfahrt,Hugh Chapman,Ari-Pekka Koivisto, Kaisa Syrjanen,Tuula Koskelainen, Saara-Elisa Peltokorpi,Piet Finckenberg,Aira Heikkila,Najah Abi-Gerges,Andre Ghetti,Paul E. Miller,Guy Page,Eero Mervaala,Norbert Nagy,Zsofia Kohajda,Norbert Jost,Laszlo Virag,Andras Varro,Julius Gy. Papp

British journal of pharmacology（2020）

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摘要

The lack of selective sodium–calcium exchanger (NCX) inhibitors has hampered the exploration of physiological and pathophysiological roles of cardiac NCX 1.1. We aimed to discover more potent and selective drug like NCX 1.1 inhibitor.

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关键词

cardiac safety,NCX,ORM&#8208,11372,positive inotropic effect,sodium&#8211,calcium exchanger

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