Large yellow croaker peroxiredoxin IV protect cells against oxidative damage and apoptosis

•A LYCK-PrxIV cell line stably expressing large yellow croaker peroxiredoxin IV was established.•The level of intracellular NO, superoxide anion and H2O2 in LYCK-PrxIV cells were significantly lower than those in control cells of LYCK-pcDNA3.1.•When exposed to H2O2, cell apoptosis was significantly alleviated in LYCK-PrxIV than in control cells.•The ROS level and ATP content were maintained more stable in LYCK-PrxIV than in LYCK-pcDNA3.1 when treated by H2O2.•The stably expressed LcPrxIV attenuated the mRNA expression change of cytokine genes when cells were treated by H2O2.