Is Toll-like receptor 4 involved in the severity of COVID-19 pathology in patients with cardiometabolic comorbidities?

Simone Cristina Soares Brandão,Júlia de Oliveira Xavier Ramos,Luca Terracini Dompieri,Emmanuelle Tenório Albuquerque Madruga Godoi,José Luiz Figueiredo,Emanuel Sávio Cavalcanti Sarinho,Sarvesh Chelvanambi,Masanori Aikawa

Cytokine & Growth Factor Reviews（2021）

引用 0|浏览0

暂无评分

摘要

•Some inflammatory diseases are related to severe forms of COVID-19, characterized by an immune system overactivation.•SARS-CoV-2 Spike protein binds with human innate immune receptors, mainly TLR4, increasing secretion of IL‐ 6 and TNF‐ α.•The main inflammatory diseases seen as risk factors for COVID-19 are hypertension, diabetes, obesity, and atherosclerosis.•The TLR4 signaling pathway is connected to inflammatory diseases seen as risk factors for COVID-19.

查看译文

关键词

SARS-CoV-2,Toll-like receptors-4,COVID-19,Cardio metabolic diseases,Obesity,Diabetes,Hypertension,Atherosclerosis

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要