Imperial Satiety Protocol: A New Non-Surgical Weight-Loss Programme, Delivered In A Health Care Setting, Produces Improved Clinical Outcomes For People With Obesity

'Imperial Satiety Protocol' (I-SatPro) is a new multifaceted approach to weight loss for people with obesity (PwO), encompassing dietary advice, time-restricted eating, physical activity and coaching to support behaviour change. Participants (n = 84) attended fortnightly I-SatPro group sessions for 30 weeks, with 70% of participants completing. On completion at 30 weeks, the mean weight loss was 15.2 +/- 1.1 kg (13.2 +/- 0.8% from baseline,P< .0001), which was maintained to 52 weeks (16.6 +/- 1.5 kg, 14.1 +/- 1.2%,P< .0001). Weight loss was not associated with reduced energy expenditure. In participants with type 2 diabetes and pre-diabetes (n = 16), glycated haemoglobin fell from 50 to 43 mmol/mol (P< .01). Systolic blood pressure fell by 12 mmHg (P< .0001). Triglycerides fell by 0.37 mmol/L (P< .01) and high-density lipoprotein rose by 0.08 mmol/L (P< .01). Short Form-36 (SF-36) functioning and wellbeing scores increased in all domains post I-SatPro intervention. For selected PwO, I-SatPro delivers clinically meaningful weight loss, and the potential for long-term health and wellbeing improvements.