TMEM41B is a pan-flavivirus host factor.

H-Heinrich Hoffmann,William M Schneider,Kathryn Rozen-Gagnon,Linde A Miles,Felix Schuster,Brandon Razooky,Eliana Jacobson,Xianfang Wu,Soon Yi,Charles M Rudin,Margaret R MacDonald,Laura K McMullan,John T Poirier,Charles M Rice

bioRxiv : the preprint server for biology（2020）

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摘要

TMEM41B and VMP1 are required for both autophagy and flavivirus infection, however, autophagy is not required for flavivirus infection.TMEM41B associates with viral proteins and likely facilitates membrane remodeling to establish viral RNA replication complexes.TMEM41B single nucleotide polymorphisms (SNPs) present at nearly twenty percent in East Asian populations reduce flavivirus infection.TMEM41B-deficient cells display an exaggerated innate immune response upon high multiplicity flavivirus infection.

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CRISPR,TMEM41B,VMP1,autophagy,coronavirus,flavivirus,flavivirus replication complex,membrane remodeling

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