Efficacy and Safety of Abbreviated Eptifibatide Treatment in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

•Eptifibatide mediates potent antithrombotic effects when used in primary PCI.•Standard eptifibatide infusion for several hours increases bleeding complications.•A novel, short eptifibatide regimen retains ischemic protection during primary PCI.•Bleeding complications are greatly reduced by the abbreviated eptifibatide regimen.•Avoiding prolonged eptifibatide treatment may improve clinical outcomes.