LXA4 protects against hypoxic-ischemic damage in neonatal rats by reducing the inflammatory response via the IκB/NF-κB pathway

Jin-Jin Zhu,Bin-Yuan Yu,Chang-Chang Fu,Min-Zhi He,Jiang-Hu Zhu,Bin-Wen Chen,Yi-Hui Zheng,Shang-Qin Chen,Xiao-Qin Fu,Pei-Jun Li,Zhen-Lang Lin

International Immunopharmacology（2020）

引用 12|浏览10

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摘要

•LXA4 against HI brain damage by protecting the integrity of blood–brain barrier.•LXA4 reduces neuronal apoptosis following HI brain damage in neonatal rats.•LXA4 exerts a neuroprotective effect via the IκB/NF-κB pathway in neonatal rats.

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关键词

Hypoxic-ischemic,Neuroinflammation,Blood–brain barrier,IκB/NF-κB

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