Plasma proteomics and lung function in four community-based cohorts
Respiratory Medicine(2021)
摘要
•Protein profiling may provide new insights into mechanisms for impaired lung function.•Twenty-two proteins were cross-sectionally associated with FEV1% in four cohorts.•Mendelian randomization analysis provided support for a causal effect of GDF-15.•GDF-15 could be a suitable target for interventions to prevent lung function decline.
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关键词
FEV1,Protein expression,Proteomics,Mendelian randomization
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