Incorporation of metal-organic frameworks into electrospun chitosan/poly (vinyl alcohol) nanofibrous membrane with enhanced antibacterial activity for wound dressing application
International Journal of Biological Macromolecules(2020)
摘要
Developing wound dressing that inhibits bacterial infection for treating complex wound healing processes has been a research hotspot. Here, we report the fabrication of Cu-MOFs (HKUST-1) incorporated electrospun chitosan/polyvinyl alcohol (HKUST-1/chitosan/PVA) fibers through the blending electrospinning for wound therapy. HKUST-1/chitosan/PVA fibers displayed satisfying physical properties, such as mechanical property, water uptake, water vapor transmission rate, etc. Cytotoxicity test indicated that HKUST-1/chitosan/PVA fibers were biocompatible and could support cell adhesion. Due to the HKUST-1 incorporation, HKUST-1/chitosan/PVA fibers exhibited the good antibacterial activity against Escherichia coli and Staphylococcus aureus with 99% antibacterial efficiency. Furthermore, in animal studies, compared with commercial chitosan dressings and chitosan/PVA fibers, HKUST-1/chitosan/PVA fibers were more efficient to heal the wound with less inflammation. In summary, the HKUST-1/chitosan/PVA fibers with good physicochemical property, biocompatibility and antibacterial property is an excellent wound dressing for full-thickness skin repair.
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关键词
Electrospinning,Chitosan,Metal-organic framework,Wound dressing
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