Niche-derived soluble DLK1 promotes glioma growth

Elisa S Grassi,Pauline Jeannot,Vasiliki Pantazopoulou,Tracy J Berg,Alexander Pietras

Neoplasia（2020）

引用 8|浏览8

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摘要

•Astrocytes secrete DLK1 after exposure to hypoxia or irradiation.•Soluble DLK1 promotes stemness in glioma, in part by increasing HIF-2alpha stabilization.•High levels of soluble DLK1 are associated with tumor aggressiveness and lethality.

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关键词

DLK1,Hypoxia,HIF-2a,Glioma,Tumor-associated astrocytes,Stem cell niche

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