Dual H-Bond Activation Of Nhc-Au(I)-Cl Complexes With Amide Functionalized Side-Arms Assisted By H-Bond Donor Substrates Or Acid Additives

Novel approach with amide-tethered H-bond donor NHC ligands enabled Au(i)-catalysis via H-bonding. The plain NHC-Au(i)-Cl complex catalysed conversions of terminal N-propynamides to oxazolines, and enyne cycloisomerization with an acid additive, in DCM at RT. DFT calculations enlightened the function of the side-arm in the activation.