Ablation of LGR4 signaling enhances radiation sensitivity of prostate cancer cells

Fang Liang,Hao Zhang,Duo Cheng,Hui Gao,Junyong Wang,Junmin Yue,Nan Zhang, Jingjing Wang,Zhaoyang Wang,Beibei Zhao

Life Sciences（2021）

引用 5|浏览9

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摘要

•Radiation upregulates the expression of LGR4 and its ligands in PCa cells;•LGR4 inhibition confers radiation sensitivity in AR positive PCa cells;•AR-CREB1 is required for DNA damage response in PCa cells;•LGR4 inhibition enhances radiation sensitivity in vivo.

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关键词

Leucine-rich repeat containing GPCR-4,Prostate cancer,Androgen receptor,Cyclic AMP response-element binding protein,Radiation,γH2A.X

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