Perturbation-Based Mapping Of Subcallosal Cingulate With Deep Brain Stimulation: Cortical Oscillatory Dynamics To Confirm Target For Electrical Neuromodulation

Perturbation-based mapping is an emerging approach to the study of circuit dynamics in the living human brain. Pulses of deep brain stimulation (DBS) to the subcallosal cingulate (SCC) evoke a coherent and reliable cortical response, recorded on the scalp surface with dense array EEG, that may reflect endogenous network dynamics. As precision targeting within the SCC region has been linked to DBS treatment efficacy, we examined features of the cortical perturbation map that change when stimulation is delivered to different locations within the surgical target region.