Promoting Coagulation and Activating SMAD3 Phosphorylation in Wound Healing Via a Dual-Release Thrombin-Hydrogel

Chongyang Wang,Tianyi Wu,Guangwang Liu,Ruoyu Cheng,Jian Fei,Xinping Song,Yimin Chai,Cunyi Fan,Xudong Liu,Wenguo Cui,Shen Liu

Chemical engineering journal（2020）

引用 14|浏览229

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摘要

•Thrombin-hydrogel targeting multiple phases of wound healing was designed.•The hydrogen bonding enhanced the mechanical property of hydrogel.•Thrombin promotes wound healing via the phosphorylation of SMAD3 (Ser204).

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关键词

Wound healing,Control release,Thrombin,Liposome,Hydrogel

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