Neuroinflammation In Mood Disorder: Emerging Biomarkers And Treatment Approaches

The NLRP3 inflammasome is a large, multiprotein complex. In response to stress, individual components re-localize from the cytosol to generate the assembled inflammasome on the outside of mitochondria; this step is considered the functional activation of the NLRP3 inflammasome. Previously we found NDUFS7, a subunit of mitochondrial complex I, to be downregulated in bipolar postmortem brain samples. This study investigates mitochondrial dysfunction as a biological source of NLRP3 upregulation in peripheral blood samples from adolescents with bipolar disorder (BD) and major depressive disorder (MDD).