Reduction in Depressive Symptoms Over the First 24 Hours in Patients With PPD Treated With the Neuroactive Steroid Brexanolone Injection

Brexanolone injection (BRX) is an intravenous formulation of allopregnanolone, a neuroactive steroid GABA-A receptor positive allosteric modulator that is indicated for the treatment of adults with postpartum depression (PPD) in the US. This analysis examined reductions in depressive symptoms over the first 24 hours of dose titration.