Longitudinal Changes in Subcallosal Cingulate Local Field Potential Features in Patients Undergoing DBS for Treatment-Resistant Depression

Subcallosal cingulate deep brain stimulation (SCC DBS) has shown promising results in treatment-resistant depression (TRD). Understanding of the local effects of DBS in targeted region could advance effective stimulation strategies. We report changes in response to acute stimulation in six SCC DBS patients that may reflect adaptive processes that underly therapeutic effects of DBS.