MP44-11 DEVELOPMENT OF A PREDICTIVE NOMOGRAM FOR CHANGES IN SEMEN PARAMETERS FOLLOWING CLOMIPHENE CITRATE THERAPY

trial has shown men treated with NatestoÒ did not have a significant suppression of semen parameters from baseline.Our objective was to evaluate outcomes in men converted from CC to NatestoÒ.METHODS: Retrospective chart review of men on CC with low libido who changed to NatestoÒ.Semen analyses, T, and E2 levels were obtained on CC and again 3 months after discontinuing CC and initiating NatestoÒ.Results are reported as means with standard deviations.RESULTS: Forty-six men desiring to maintain fertility potential changed from CC to NatestoÒ and 15 of them had reached the 3 months post-NatestoÒ treatment to evaluate their responses.The mean age was 39 (7) years and they had improvements in T levels on both treatments, but significantly higher E2 levels on CC than baseline or on NatestoÒ.There was no significant change in any semen parameters comparing them while on CC to after converting to NatestoÒ.All patients reported improved libido after converting from CC to NatestoÒ.CONCLUSIONS: Although men reach eugonadal T levels on both CC and NatestoÒ, CC nearly doubled E2 levels from baseline, and converting men from CC to NatestoÒ returned E2 to baseline levels.There was not a detrimental effect on semen parameters, and there was subjective reporting of improved libido after converting from CC to NatestoÒ.