Tu1613 GERMLINE RET AND MAPT (TAU) MUTATIONS AND PANCREATIC CANCER: AN EXPLORATORY STUDY.

Background Acute pancreatitis (AP) is a sudden inflammation of the pancreas, and biliary pancreatitis remains the most common cause of AP.Endoscopic retrograde cholangiopancreatography (ERCP) is very commonly used in AP with coexisting acute cholangitis or biliary obstruction.There was a need for a nationwide study to evaluate ERCP utilization trends and health-care costs amongst AP patients.Aim We sought to determine the prevalence trend, hospitalization cost and stay, and predictors of utilization of ERCP amongst patients with AP.Methods We performed a population-based retrospective analysis of the Nationwide Inpatient Sample data (years 2003-2014) in adult (>18 years) AP hospitalizations using ICD-9-CM codes.We performed a chi-square test, t-test, and Jonckheere's trend test to evaluate characteristics of the ERCP cohort, prevalence trend, hospital utilization cost, and length of stay (LOS).The multivariate survey logistic regression model was weighted to account for sampling strategy, to evaluate predictors of utilization for ERCP among AP hospitalization.The model was adjusted for patient's demographics like gender and race, comorbidities like hypertension, diabetes, hypercholesterolemia, substance, alcohol and tobacco abuse, HIV, renal failure, Charlson's Comorbidity Index, and admission and hospitallevel characteristics admission day, type, payer, location, and teaching status of the hospital.Results In this analysis, among 2,632,309 hospitalizations for AP, 49108 (1.87%) had ERCP.The prevalence trend of ERCP declined from 3.88% in year 2003 to 0.97% in year 2014.(pTrend<0.0001).Patients with ERCP were older (>55 year old) (53.01%vs 39.36%; p<0.0001), female (58.45% vs 48.04%; p<0.0001), hispanic (16.30% vs 12.86%; p<0.0001), utilizing medicare (40.29% vs 31.88%;p<0.0001), elective admission (8.15% vs 4.98%; p<0.0001), and with gallbladder etiology (65.98% vs 26.06%; p<0.0001).AP hospitalization with ERCP had higher cost of utilization ($56338 vs $31261; diff=$25077; p<0.0001) and mean LOS (8.6 vs 5.1 days; diff=3.5;p<0.0001).In regression analysis, old adults [Odds ratio (OR):1.087;Confidence interval (CI):1.008-1.173),hispanic (OR:1.086;CI:1.