The Combined Effect Of Gender And Age On Remission Rate In Patients With Newly Diagnosed Type 2 Diabetes After Intensive Insulin Therapy

According to our previous study, short-term intensive insulin therapies(SIIT) can induce long-term remission from T2DM in half of the patients. It’s interesting that young male patients seem to recover better. In order to examine the combined effect of gender and age on remission of T2DM, an observation of 160 patients with newly diagnosed T2DM (n=160, 103 male, aged 50±10 ys, HbA1C 11±2.1%) after 2-week therapy were studied. Men and women differed in age with T2DM onset (47±10 ys vs. 54 ±9ys, Fig A.). The average remission time in a 5-year follow-up was 30 months for men and 21 months for women(Fig B.). But in the same age stage, the remission time was similar between male and female, as well as the improvement of HOMA-B and HOMA-IR by this therapy(Fig C., D., E.).There were no statistical gender differences in each age stage. In conclusion, the gender differences in age of onset for T2DM affected the remission rate from T2DM after SIIT. The male often has diabetes earlier and was better to recover. Disclosure W. Xuesi: None. Z. Huang: None. L. Liu: None. Y. Li: None. Funding National Key Research and Development Program of China (2018YFC1314100)