Low-dimensional compounds containing bioactive ligands. Part XV: Antiproliferative activity of tris(5-nitro-8-quinolinolato)gallium(III) complex with noticeable selectivity against the cancerous cells

Miroslava Litecká,Jitka Prachařová,Jana Kašpárková,Viktor Brabec,Romana Smolková,Róbert Gyepes,Jakub Obuch,Vojtěch Kubíček,Ivan Potočňák

Polyhedron（2020）

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摘要

Three gallium(III) complexes with 8-quinolinol derivatives, [Ga(NQ)3] (1), Na3[Ga(SQ)3]·7H2O·3NaCl (2) and [Ga(ClNQ)3]·MeOH (3) were prepared and characterised by necessary physicochemical methods. Biological studies revealed high antiproliferative activity of 1 with selectivity for cancer cell lines over normal cell line better than cisplatin while 2 displayed noticeable antiradical activity.

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关键词

5-Nitro-8-quinolinol,5-Sulfo-8-quinolinol,5-Chloro-7-nitro-8-quinolinol,Gallium(III) complexes,Antiproliferative activity,Antiradical activity

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