Development Of Oil-In-Water Microemulsion Encapsulating Vitamin E For Thermal And Hydrolysis Degradation Study

Vitamin E is widely used for medicinal and cosmeceuticals purposes. However, it is easy to degrade by the environment. In this study, the degradation of Gold Tri.E (TM) TPA was studied and determined. Gold Tri.E (TM) is a mixture of Vitamin E homologs (tocotrienol and tocopherol) extracted from palm oil (Elais Guineensis). A nanocarrier system has been optimized to encapsulate Gold Tri.E (TM) from degrading and increasing its stability as a bioactive compound. An oil-in-water (o/w) microemulsion was formulated and optimized as the best carrier to encapsulate Gold Tri.E (TM) with the mean particle size of 32.60 +/- 3.60 nm and 99.99 +/- 0.01% encapsulation efficiency (EE). Degradation of the Gold Tri.E (TM) in o/w microemulsion was significantly reduced as compared to the bare Gold Tri.E (TM) . This suggested that the system could protect Gold Tri.E (TM) from thermal and hydrolysis degradation. Thus, the ease of preparation, low-cost production, and small particle size obtained when Gold Tri.E (TM) encapsulated in this system give promising drug delivery system to encapsulate, protect, and increase the shelf life of Gold Tri.E (TM) .