Nucleic acid based tetrahedral framework DNA nanostructures for fibrotic diseases therapy

Tianxu Zhang,Yang Gao,Dexuan Xiao,Junyao Zhu,Mi Zhou,Songhang Li,Mei Zhang,Yunfeng Lin,Xiaoxiao Cai

Applied Materials Today（2020）

引用 6|浏览24

暂无评分

摘要

•Novel tetrahedral framework DNA nanostructures (TFNAs) were synthesized and firstly introduced into fibrotic diseases treatment.•TFNAs reduced LPS-induced ROS overproduction which is a crucial stimulator for fibrogenesis.•TFNAs suppress extracellular matrix (ECM) production and epithelial-mesenchymal transition (EMT) process.•This study provides a new prospect for the application of DNA nanomaterials for fibrotic diseases therapy.

查看译文

关键词

Tetrahedral DNA nanostructures,Self-assembly,DNA nanomaterials,Fibrotic diseases

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要