Design of a High Voltage Pulse Generator with Large Width Adjusting Range for Tumor Treatment

The unique biological effects stimulated by short pulsed electric field have many applications in tumor treatment, such as irreversible electroporation, electrochemotherapy, gene transfection and immune therapy. These biological effects require high voltage pulses with different pulse width in the range from nanoseconds to hundreds of microseconds. To fulfill this requirement, a compact high voltage pulse generator has been designed based on a switchable capacitor array and a SiC MOSFET switching array. The proposed pulse generator has one output channel with an adjustable pulse width from 100 ns to 100 mu s, an amplitude range from 0 kV to 2 kV, a repetition rate less than 1.2 kHz and a voltage drop less than 5%. The mechanism of the stacked switches circuit was investigated, in connection with a switchable capacitor array. The introduction of a switchable capacitor array extends the pulse width from nanosecond scale and microsecond scale compared with other similar design methods. The pulse generator has been designed in simulation and implemented in experiment. The developed pulse generator provides a convenient and economical tool for the further studies of the unique biological effects stimulated by different pulsed electric fields for tumor treatment.