From bench to bedside: biosensing strategies to evaluate endocrine disrupting compounds based on epigenetic events and their potential use in medicine.

•Epigenetic events have a great potential to provide outstanding information about the exposition of EDCs.•“The sixth base” (5-hmC) is an appealing epigenetic marker for environmental biosensors.•Post translational modifications has been measured via enzyme activity towards drug development and clinical diagnosis.•Personal health outcomes are the result of the interaction between the exposome and the individual genome.