Structural Mimicry Drives HIV-1 Rev-Mediated HERV-K Expression

Ina P O'Carroll,Lixin Fan,Tomáš Kroupa,Erin K McShane, Christophe Theodore,Elizabeth A Yates,Benjamin Kondrup,Jienyu Ding, Tyler S Martin,Alan Rein,Yun-Xing Wang

Journal of Molecular Biology（2020）

引用 7|浏览95

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摘要

•HIV-1 Rev binds to and mediates the nuclear export of the HERV-K RcRE.•The topological structure of the HERV-K RcRE resembles that of the HIV-1 RRE.•The unique long stem oscillates between folded and extended conformations.•RcRE variants defective of Rev-binding and nuclear export activity have distorted structures.•The first topological structure for a HERV molecule is reported.

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关键词

HERV-K,RcRE,small-angle X-ray scattering,atomic force microscopy,HIV-1 Rev

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