Nesfatin Level is an Early Indicator of Atherosclerosis in Type 1 Diabetic Patients

To evaluate nesfatin as an indicator of early atherosclerotic changes in patients with type 1 diabetes.Our study encompassed seventy diabetic patients (type 1) together with fifty healthy volunteers of matched age and sex.The patients group showed a mean age of 17.99 +/- 2.59 yrs, the duration of diabetes showed a mean of 10.91 +/- 3.54 yrs and the disease onset mean was 7.00 +/- 3.28 yrs.Serum levels of lipid profile, nesfatin and oxidized low-density lipoprotein (OxLDL) were determined. Glycosylated HA1C was assessed. Collection of urine samples for estimation of albumin/creatinine ratio. Determination of Carotid (cIMT) and aortic (aIMT) intima-media thickness. Diabetic patients showed significantly higher levels of Nesfatin, OxLDL, albumin/creatinine ratio, cIMT and aIMT.A significant positive correlation between Nesfatin with cholesterol and aIMT was established.On the contrary it had a negative correlation with HDL. OxLDL showed a significant positive correlation with waist/hip ratio and HbA1c. Nesfatin had a good diagnostic accuracy (AUC = 0.6) in patients with aIMT and cIMT. Nesfatin had a good sensitivity and specificity in relation to aIMT (68.3 and 60 respectively) than cIMT (90.9 and 37.5 respectively).Nesfatin is higher in diabetic patients and had a good diagnostic accuracy for early detection of atherosclerosis.