Renal function and metabolic change after orthotopic bladder substitution in men: A single-institution study

To evaluate metabolic outcomes, renal function and metabolic change after, radical cystectomy (RC) and orthotopic bladder substitution in single-institution. A retrospective review of bladder cancer (BC) patients, who received radical cystectomy with orthotopic bladder substitution were identified from a medical record. We collected data from the years; 2007 to 2016. We enrolled 26 patients, who received RC, with their creatinine level and electrolyte having been collected as well as their longitudinal change of creatinine and electrolyte were assessed. From these 26 patients, the median age was 62.6 years. Median followup, after radical cystectomy from patients still living at last follow up was; 87 35 weeks. The mean preoperative creatinine level was 1.15 mg/dL, whilst the mean creatinine levels. at 1, 3, 6, 12, 24 months, were; 1.69 mg/dL, 1.64 mg/dL, 1.66 mg/dL, 1.82 mg/dL, 1.97 mg/dL respectively. BC patients, with RC with orthotopic bladder substitution, have the potential of renal deterioration and a lifelong risk of chronic kidney disease (CKD). Regular monitoring of upper urinary tract imaging, and renal function will delay CKD status along with early diagnosis and treatment of modifiable factors.