Association Of Beta-Lactam Allergy Documentation And Prophylactic Antibiotic Use In Surgery: A National Cross-Sectional Study Of Hospitalized Patients

Alternative antibiotics for surgical prophylaxis are associated with increased adverse events and surgical site infection compared to cefazolin. In a sample of perioperative inpatients from 100 hospitals in the United States, cefazolin was 9-fold less likely to be used in patients with a documented beta-lactam allergy whereas clindamycin was 45-fold more likely.