Lmx1a and Lmx1b are Redundantly Required for the Development of Multiple Components of the Mammalian Auditory System

Neuroscience(2021)

引用 19|浏览17
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摘要
•Combined loss of Lmx1a/b disrupts auditory inner ear development, preventing formation of the organ of Corti.•Loss of Lmx1a and Lmx1b leads to milder inner ear vestibular innervation abnormalities.•In Lmx1a/b double mutants, vestibular afferents aberrantly project to the hindbrain dorsal midline.•Combined loss of Lmx1a/b prevents the development of excitatory neurons of cochlear and vestibular nuclei.
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