Development of new tools for molecular diagnosis of hematologic malignancies

Molecular alterations represent diagnostic and prognostic factors in hematologic diseases. Their presence can anticipate the malignancy outcome or confer responsiveness to specific treatments. Here we present the development of new assays based on an innovative technology, named loop-mediated isothermal amplification (LAMP), for the molecular detection of these alterations in a simple, fast and accurate way. These assays can identify molecular aberrations in a non polymerase chain reaction-based manner, starting directly from DNA or RNA in a single-tube close format and in a short time frame.