Quality of life in survivors of stage I-II breast cancer, 10 years outcome of a randomized clinical trial comparing post-operative hypofractionation with Tomotherapy versus conventional radiation treatment (TomoBreast)

Purpose: TomoBreast compared normofractionated conventional radiotherapy (CR) with hypofractionated tomotherapy (TT), on the hypothesis that normal-tissue sparing by tomotherapy should reduce lung-heart toxicity. Quality of life (QOL) outcomes at 8-12 years are presented herein. Materials-Methods: The trial enrolled 123 women in 2007-2011, 64 were randomized to CR, 59 to TT. CR delivered 50 Gy in 25 fractions/5 weeks to the breast/chest wall and regional nodes if node-positive, 16 Gy/8 fractions/1.6 weeks sequential-boost in patients who underwent lumpectomy. TT delivered 42 Gy/15 fractions/3 weeks to the breast/chest wall and regional nodes if node-positive, concurrently with chemotherapy by institution9s practice, 51 Gy simultaneous-integrated-boost in patients with lumpectomy. QOL assessments used the EORTC questionnaires QLQ-C30 and QLQ-BR23. Intent-to-treat analyses used the linear mixed-effect model (LMM), and survival analysis applied to time to \u003e10% deterioration (TTD) in QOL-measures. A cardiorespiratory composite TTD event was defined as deterioration in any of the dyspnea, fatigue, physical functioning, or pain measures. Results: On survival and tumor control, there were no differences in overall and disease-free survival. On QOL analysis by LMM, TT in late \u003e2 years period was associated with poorer nausea-scores (modeled deterioration 21.2%, P Citation Format: Hilde Van Parijs, Vincent Vinh-Hung, Christel Fontaine, Guy A Storme, Nele Adriaenssens, Shane Hanon, Marian Vanhoeij, Maryam B Lustberg, Nicole Williams, Dung M Nguyen, Nam P Nguyen, Claire Verschraegen, Mark De Ridder. Quality of life in survivors of stage I-II breast cancer, 10 years outcome of a randomized clinical trial comparing post-operative hypofractionation with Tomotherapy versus conventional radiation treatment (TomoBreast) [abstract]. In: Proceedings of the 2019 San Antonio Breast Cancer Symposium; 2019 Dec 10-14; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(4 Suppl):Abstract nr P2-13-01.