Absolute Configuration Determination of Two Drimane Sesquiterpenoids from the Endophytic Fungi Talaromyces Purpureogenus of Panax Notoginseng

Two drimane sesquiterpenoids (1, 2) were isolated from cultures of the fungus Talaromyces purpureogenus. The planar structures were well established by NMR and mass spectrometry, and the absolute configurations(AC) were determined by comparing experimental electronic circular dichroism(ECD) and optical rotation(OR) of compounds 1 and 2 with the calculated ECD and OR data using quantum methods. Compounds 1 and 2 were evaluated for antibacterial activities against four spices of pathogenic bacteria, and the results showed that compound 1 had weak antibacterial activities against Escherichia coli (MIC = 25 mu mol/L).