CONSIDERATIONS REGARDING THE BIOMARKER VALUE OF CIRCULANT CONCENTRATION OF PON1 IN PATIENTS WITH HEART FAILURE THROUGH CHRONIC ISCHEMIC CARDIOMYOPATHY

The study has a double objective: to determine the clinical significance as a possible biomarker for risk of heart failure of one of the paraoxonase family members, PON1 and highlight a possible correlation between circulating levels of isozyme with the value of ejection fraction. As etiology of heart failure, there were selected for the study only the cases suffering from chronic ischemic heart disease without myocardial infarction history. This was due to the fact that myocardial hypoxia is widely recognised scientifically as the main source of production of oxidizing species, among different causes generating myocardial contractile deficit.