Synthesis and Antibacterial Activities of Halogenated Hydroxy Diphenyl Ether Derivatives

Seven halogenated hydroxy diphenyl ether derivatives have been synthesized, 6 of them are new compounds and their structures were identified by H-1 NMR, HR-MS and IR spectra. The antibacterial activities of all the present compounds were tested via the agar-well diffusion method in vitro in the concentration of 50 mu g/mL. The results showed that most of the new compounds exhibited antibacterial activities against the tested bacterium.