Development and Application of Immobilized Chiral Columns based on Polysaccharide Derivatives, as Common Name "i-CHIRAL" Columns

The development of new chiral products in pharmaceutical, food and fragrance industries requires accurate and rapid evaluation of optical purity. Nowadays, polysaccharide-derived chiral stationary phases are considered as the first choice tools for the determination of enantiomeric excess by HPLC. In the present article, a brief overview about coated type polysaccharide-derived chiral columns is introduced. From this basis, the main factors catalyzing the development and commercialization of the new generation of immobilized type chiral columns are described. This successful breakthrough was based on their excellent performance and separation abilities. In the last section, the scope of these new chromatographic products as packing materials, flash-columns and TLC formats are reviewed.