Theoretical and Experimental Investigations on Inclusion Complex beta-Cyclodextrin and Sulcatone: A Cardiovascular Activity Evaluation

In this paper, we have applied state-of-the-art technologies and new investigations were developed focusing on obtaining simple and inexpensive molecules for treating cardiovascular diseases, as they are considered the leading cause of death in the world. For the first time, the inclusion complex of sulcatone (SU) and beta-cyclodextrin (beta-CD) was achieved (using a spray drier) and characterized making use of spectroscopic, thermal and computational methods. In addition. the system was evaluated regarding its vasorelaxant properties. Evidence of the inclusion complex formation was provided using different techniques. such as X-ray diffraction (XRD), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), Fourier transform infrared (FTIR), and H-1 nuclear magnetic resonance (NMR) spcctroscopies and then deduced by pharmacological experiments, which showed significant changes in relation to the initial material.