Microwave-Assisted Synthesis of Positional Isomeric Dihydro-triazolo-pyrimido-acridines and Biological studies
CHEMISTRYSELECT(2020)
摘要
Microwave synthetic methodologies were proposed for the preparation of positional isomeric dihydro-triazolo-pyrimido-acridines, 3a-j and 9a-h via friedlander synthesis using response surface methodology (RSM). The advantages of these methodologies over conventional methods are it provides good yields with short reaction times. Free radical scavenging and antifungal studies were performed for compounds 3a-j and 9a-h. The results of antioxidant assay revealed that compounds 3c, 3d and 9b exhibited excellent property whereas compounds 3a and 9a showed significant antifungal property against Aspergillus flavus (A.flavus) and Aspergillus niger (A. niger).
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关键词
Antifungal assay,Antioxidant,Friedlander synthesis,Microwave,Positional isomers,Triazolo-pyrimido-acridines
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