Synthesis of 1H-Thiopyrano[4,3-c]quinoline Scaffold via One-pot Three-component Cyclization
CHEMISTRYSELECT(2019)
摘要
A convenient and effective one-pot synthetic method for functionalized 1H-thiopyrano[4,3-c]quinoline scaffold via three-component cyclization is described. This procedure contains the reaction between 2-chloroquinoline-3-carbaldehyde and 2 equivalents of phenacyl thiocyanate in the presence of triethylamine in absolute ethanol at room temperature with good yield. This eco-friendly method has advantages such as reduction of waste, short synthetic procedure, and little amount of required reagents.
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关键词
2-chloroquinoline-3-carbaldehyde,phenacyl thiocyanate,1H-thiopyrano[4,3-c]quinoline,thiopyranoquinoline
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