Meglumine Promoted Strategy: Environmentally Benign Protocol towards the Synthesis of Polysubstituted 2-Aminopyrroles in Aqueous Condition

A facile and highly efficient protocol for the one-pot, four-component synthesis of polysubstituted 2-aminopyrroles by using glyoxal monohydrate derivatives, anilines, coumarin derivatives, and malononitrile has been developed. Meglumine used as an inexpensive, biodegradable and reusable catalyst. Simplicity, green solvent, easy work-up process, cost effective and reusability of the promoter are the main advantages of reported methodology.