Inactivation of Serca2 Redox Cysteine 674 Promotes Pulmonary Artery Remodeling by Activating Ire1A-xbp1 Pathway

Introduction: Sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2 (SERCA2) is a key enzyme for maintaining Ca2+ homeostasis in vasculature. The decrease of SERCA2a (one of SERCA2 subtypes) is related ...