Insulin-Like Growth Factor Binding Protein 2 Overexpression Leads to Aortic Hypocontractility Through Vascular Smooth Muscle Phenotypic Switching

Thomas Slater, Alexander-Francisco Bruns,Natalie Haywood,Mohammed Abdul Waduud,Karen Hemmings,Katherine Bridge, Asjad Visnagri,Andrew Walker,Michael Drozd,Marc Bailey,Nadira Y. Yuldasheva,Karen E. Porter,Richard Cubbon,Mark Kearney,Stephen B. Wheatcroft

CIRCULATION（2019）

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摘要

Introduction: Insulin-like growth factor binding proteins (IGFBP) exhibit multiple effects beyond regulation of IGFs. IGFBP2 is upregulated in vascular smooth muscle cells (VSMC) in human atheroscl...

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