The impact of lung cancer resection surgery on fibrinogen and C-reactive protein and their relationship with patients outcomes: A prospective follow up study

Objective: To assess the pre and postoperative systemic inflammatory markers of patients undergoing lung cancer resection (LR). Methods: Prospective study conducted with 48 patients submitted to LR. The patients were assessed before and 1 month after surgery through of fibrinogen, C-reative protein (CRP), pulmonary function tests, 6- minute Walk Test (6MWT), maximal inspiratory and expiratory pressure (PImax and PEmax), anxiety and depression scale and karnofsky performance status scale. Results: Fibrinogen and CRP were higher 1 month after surgery, only the CRP was statistically significant (p = 0.03). The 6MWT, PImax, PEmax, FEV1(%) and FVC(%) decreased after surgery with p= 0.001. Anxiety and depression improved and Karnofsky decrease after surgery (p = 0.03, p = 0.01, p = 0.02; respectively). Change in CRP score following LR correlated significantly with changes in fibrinogen (r = 0.40; p = 0.003), change in Karnofsky scale (r = −0.50; p Conclusion: LR was associated with increased level of CRP, 1 month after surgery, and correlated directly with change in fibrinogen and inversely with measurement of performance status. VATS provided lower level of fibrinogen after surgery.